4b0h

From Proteopedia

proteopedia linkproteopedia link

Template:STRUCTURE 4b0h

Contents 1 B. subtilis dUTPase YncF in complex with dU, PPi and Mg b (P212121) 2 Function 3 About this Structure 4 Reference

B. subtilis dUTPase YncF in complex with dU, PPi and Mg b (P212121)

Template:ABSTRACT PUBMED 23897460

Function

[YNCF_BACSU] This enzyme is involved in nucleotide metabolism: it produces dUMP, the immediate precursor of thymidine nucleotides and it decreases the intracellular concentration of dUTP so that uracil cannot be incorporated into DNA (By similarity).

About this Structure

4b0h is a 3 chain structure with sequence from Bacillus subtilis. Full crystallographic information is available from OCA.

Reference

• Garcia-Nafria J, Timm J, Harrison C, Turkenburg JP, Wilson KS. Tying down the arm in Bacillus dUTPase: structure and mechanism. Acta Crystallogr D Biol Crystallogr. 2013 Aug;69(Pt 8):1367-80. doi:, 10.1107/S090744491300735X. Epub 2013 Jul 13. PMID:23897460 doi:10.1107/S090744491300735X