4lov

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Template:STRUCTURE 4lov

Contents

Crystal structure of FimH in complex with Heptylmannoside

Template:ABSTRACT PUBMED 24476493

Function

[FIMH_ECOLI] Involved in regulation of length and mediation of adhesion of type 1 fimbriae (but not necessary for the production of fimbriae). Adhesin responsible for the binding to D-mannose. It is laterally positioned at intervals in the structure of the type 1 fimbriae. In order to integrate FimH in the fimbriae FimF and FimG are needed.

About this Structure

4lov is a 1 chain structure. Full crystallographic information is available from OCA.

Reference

  • Vanwetswinkel S, Volkov AN, Sterckx YG, Garcia-Pino A, Buts L, Vranken WF, Bouckaert J, Roy R, Wyns L, van Nuland NA. Study of the Structural and Dynamic Effects in the FimH Adhesin upon alpha-d-Heptyl Mannose Binding. J Med Chem. 2014 Feb 7. PMID:24476493 doi:http://dx.doi.org/10.1021/jm401666c

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