4kui

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Template:STRUCTURE 4kui

Contents 1 Crystal structure of N-terminal acetylated yeast Sir3 BAH domain 2 Function 3 About this Structure 4 Reference

Crystal structure of N-terminal acetylated yeast Sir3 BAH domain

Template:ABSTRACT PUBMED 23934152

Function

[SIR3_YEAST] The proteins SIR1 through SIR4 are required for transcriptional repression of the silent mating type loci, HML and HMR. The proteins SIR2 through SIR4 repress mulitple loci by modulating chromatin structure. Involves the compaction of chromatin fiber into a more condensed form.

About this Structure

4kui is a 1 chain structure with sequence from Saccharomyces cerevisiae s288c. Full crystallographic information is available from OCA.

Reference

• Yang D, Fang Q, Wang M, Ren R, Wang H, He M, Sun Y, Yang N, Xu RM. Nalpha-acetylated Sir3 stabilizes the conformation of a nucleosome-binding loop in the BAH domain. Nat Struct Mol Biol. 2013 Aug 11. doi: 10.1038/nsmb.2637. PMID:23934152 doi:10.1038/nsmb.2637