4ian
From Proteopedia
Contents |
Crystal Structure of apo Human PRPF4B kinase domain
Template:ABSTRACT PUBMED 24003220
Function
[PRP4B_HUMAN] Has a role in pre-mRNA splicing. Phosphorylates SF2/ASF.
About this Structure
4ian is a 2 chain structure with sequence from Streptomyces aureorectus. Full crystallographic information is available from OCA.
Reference
- Gao Q, Mechin I, Kothari N, Guo Z, Deng G, Haas K, McManus J, Hoffmann D, Wang A, Wiederschain D, Rocnik J, Czechtizky W, Chen X, McLean L, Arlt H, Harper D, Liu F, Majid T, Patel V, Lengauer C, Garcia-Echeverria C, Zhang B, Cheng H, Dorsch M, Huang SM. Evaluation of cancer dependence and druggability of PRP4 kinase using cellular, biochemical, and structural approaches. J Biol Chem. 2013 Sep 3. PMID:24003220 doi:10.1074/jbc.M113.473348
