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4lmg

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Template:STRUCTURE 4lmg

Contents

Crystal structure of AFT2 in complex with DNA

Template:ABSTRACT PUBMED 24591629

Function

[AFT2_YEAST] Transcription factor required for iron homeostasis and resistance to oxidative stress. With RCS1, activates the gene expression in response to low-iron conditions, also called iron regulon.[1] [2] [3] [4] [5]

About this Structure

4lmg is a 8 chain structure with sequence from Baker's yeast. Full crystallographic information is available from OCA.

Reference

  • Poor CB, Wegner SV, Li H, Dlouhy AC, Schuermann JP, Sanishvili R, Hinshaw JR, Riggs-Gelasco PJ, Outten CE, He C. Molecular mechanism and structure of the Saccharomyces cerevisiae iron regulator Aft2. Proc Natl Acad Sci U S A. 2014 Mar 18;111(11):4043-8. doi:, 10.1073/pnas.1318869111. Epub 2014 Mar 3. PMID:24591629 doi:http://dx.doi.org/10.1073/pnas.1318869111
  1. ↑ Blaiseau PL, Lesuisse E, Camadro JM. Aft2p, a novel iron-regulated transcription activator that modulates, with Aft1p, intracellular iron use and resistance to oxidative stress in yeast. J Biol Chem. 2001 Sep 7;276(36):34221-6. Epub 2001 Jul 11. PMID:11448968 doi:http://dx.doi.org/10.1074/jbc.M104987200
  2. ↑ Rutherford JC, Jaron S, Ray E, Brown PO, Winge DR. A second iron-regulatory system in yeast independent of Aft1p. Proc Natl Acad Sci U S A. 2001 Dec 4;98(25):14322-7. PMID:11734641 doi:http://dx.doi.org/10.1073/pnas.261381198
  3. ↑ Rutherford JC, Jaron S, Winge DR. Aft1p and Aft2p mediate iron-responsive gene expression in yeast through related promoter elements. J Biol Chem. 2003 Jul 25;278(30):27636-43. Epub 2003 May 19. PMID:12756250 doi:http://dx.doi.org/10.1074/jbc.M300076200
  4. ↑ Rutherford JC, Ojeda L, Balk J, Muhlenhoff U, Lill R, Winge DR. Activation of the iron regulon by the yeast Aft1/Aft2 transcription factors depends on mitochondrial but not cytosolic iron-sulfur protein biogenesis. J Biol Chem. 2005 Mar 18;280(11):10135-40. Epub 2005 Jan 13. PMID:15649888 doi:http://dx.doi.org/10.1074/jbc.M413731200
  5. ↑ Courel M, Lallet S, Camadro JM, Blaiseau PL. Direct activation of genes involved in intracellular iron use by the yeast iron-responsive transcription factor Aft2 without its paralog Aft1. Mol Cell Biol. 2005 Aug;25(15):6760-71. PMID:16024809 doi:http://dx.doi.org/25/15/6760

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