4l9o
From Proteopedia
Contents |
Crystal Structure of the Sec13-Sec16 blade-inserted complex from Pichia pastoris
Template:ABSTRACT PUBMED 24006484
Function
[SEC13_PICPG] Component of the coat protein complex II (COPII) which promotes the formation of transport vesicles from the endoplasmic reticulum (ER). The coat has two main functions, the physical deformation of the endoplasmic reticulum membrane into vesicles and the selection of cargo molecules. It also functions as a component of the nuclear pore complex (NPC). NPC components, collectively referred to as nucleoporins (NUPs), can play the role of both NPC structural components and of docking or interaction partners for transiently associated nuclear transport factors. SEC13 is required for efficient mRNA export from the nucleus to the cytoplasm and for correct nuclear pore biogenesis and distribution (By similarity).
About this Structure
4l9o is a 2 chain structure with sequence from Komagataella pastoris (strain gs115 / atcc 20864). Full crystallographic information is available from OCA.
Reference
- Bharucha N, Liu Y, Papanikou E, McMahon C, Esaki M, Jeffrey PD, Hughson FM, Glick BS. Sec16 influences transitional ER sites by regulating rather than organizing COPII. Mol Biol Cell. 2013 Sep 4. PMID:24006484 doi:10.1091/mbc.E13-04-0185
