4m3l
From Proteopedia
Contents |
Crystal Structure of the coiled coil domain of MuRF1
Function
[TRI63_HUMAN] E3 ubiquitin ligase. Regulates proteasomal degradation of cardiac troponin I/TNNI3 and probably of other sarcomeric-associated proteins. May play a role in striated muscle atrophy and hypertrophy by regulating an anti-hypertrophic PKC-mediated signaling pathway. May regulate the organization of myofibrils through TTN in muscle cells.[1]
About this Structure
4m3l is a 4 chain structure. Full crystallographic information is available from OCA.
Reference
- ↑ McElhinny AS, Kakinuma K, Sorimachi H, Labeit S, Gregorio CC. Muscle-specific RING finger-1 interacts with titin to regulate sarcomeric M-line and thick filament structure and may have nuclear functions via its interaction with glucocorticoid modulatory element binding protein-1. J Cell Biol. 2002 Apr 1;157(1):125-36. Epub 2002 Apr 1. PMID:11927605 doi:http://dx.doi.org/10.1083/jcb.200108089
