Structural highlights
Publication Abstract from PubMed
The synthesis and hit-to-lead SAR development from a pyrazolo[1,5-a]pyrimidine-derived hit 5 to the identification of a series of potent, pan-Pim inhibitors such as 11j are described.
Discovery of pyrazolo[1,5-a]pyrimidine-based Pim inhibitors: A template-based approach.,Dwyer MP, Keertikar K, Paruch K, Alvarez C, Labroli M, Poker C, Fischmann TO, Mayer-Ezell R, Bond R, Wang Y, Azevedo R, Guzi TJ Bioorg Med Chem Lett. 2013 Nov 15;23(22):6178-82. doi:, 10.1016/j.bmcl.2013.08.110. Epub 2013 Sep 7. PMID:24091081[1]
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.
References
- ↑ Dwyer MP, Keertikar K, Paruch K, Alvarez C, Labroli M, Poker C, Fischmann TO, Mayer-Ezell R, Bond R, Wang Y, Azevedo R, Guzi TJ. Discovery of pyrazolo[1,5-a]pyrimidine-based Pim inhibitors: A template-based approach. Bioorg Med Chem Lett. 2013 Nov 15;23(22):6178-82. doi:, 10.1016/j.bmcl.2013.08.110. Epub 2013 Sep 7. PMID:24091081 doi:http://dx.doi.org/10.1016/j.bmcl.2013.08.110
