4l9h

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Template:STRUCTURE 4l9h

Contents

Crystal structure of the FP domain of human F-box protein Fbxo7(SeMet)

Disease

[FBX7_HUMAN] Parkinsonian-pyramidal syndrome. The disease is caused by mutations affecting the gene represented in this entry.

Function

[FBX7_HUMAN] Substrate recognition component of a SCF (SKP1-CUL1-F-box protein) E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins. Recognizes BIRC2 and DLGAP5.[1] [2]

About this Structure

4l9h is a 1 chain structure. Full crystallographic information is available from OCA.

Reference

  1. ↑ Hsu JM, Lee YC, Yu CT, Huang CY. Fbx7 functions in the SCF complex regulating Cdk1-cyclin B-phosphorylated hepatoma up-regulated protein (HURP) proteolysis by a proline-rich region. J Biol Chem. 2004 Jul 30;279(31):32592-602. Epub 2004 May 15. PMID:15145941 doi:http://dx.doi.org/10.1074/jbc.M404950200
  2. ↑ Chang YF, Cheng CM, Chang LK, Jong YJ, Yuo CY. The F-box protein Fbxo7 interacts with human inhibitor of apoptosis protein cIAP1 and promotes cIAP1 ubiquitination. Biochem Biophys Res Commun. 2006 Apr 21;342(4):1022-6. Epub 2006 Feb 21. PMID:16510124 doi:http://dx.doi.org/10.1016/j.bbrc.2006.02.061

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