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4njp

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Template:STRUCTURE 4njp

Contents

Proteolysis inside the membrane is a rate-governed reaction not Driven by substrate affinity

Function

[GLPG_ECOLI] Rhomboid-type serine protease that catalyzes intramembrane proteolysis.[1] [2]

About this Structure

4njp is a 1 chain structure. Full crystallographic information is available from OCA.

Reference

  1. ↑ Wu Z, Yan N, Feng L, Oberstein A, Yan H, Baker RP, Gu L, Jeffrey PD, Urban S, Shi Y. Structural analysis of a rhomboid family intramembrane protease reveals a gating mechanism for substrate entry. Nat Struct Mol Biol. 2006 Dec;13(12):1084-91. Epub 2006 Nov 10. PMID:17099694 doi:10.1038/nsmb1179
  2. ↑ Maegawa S, Ito K, Akiyama Y. Proteolytic action of GlpG, a rhomboid protease in the Escherichia coli cytoplasmic membrane. Biochemistry. 2005 Oct 18;44(41):13543-52. PMID:16216077 doi:10.1021/bi051363k

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OCA

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