Function
D-aminoacylase (DAA) hydrolyzes N-acyl neutral D-amino acids. DAA is a zinc-assisted enzyme. [1]
Relevance
DAA which
Disease
Mutation in DAA1 causes a dysfunctional urea cycle. Mutation in DAA2 causes Canavan's Disease,
Structural highlights
DAA contains a Zn-binding domain and a dimerization domain.
3D structures of D-aminoacylase
Updated on 20-December-2015
1m7j, 1v51 – AfDAA + Zn – Alcaligenes faecalis
1rjq, 1rjr, 1v4y - AfDAA (mutant) + Zn
1rjp - AfDAA + Zn + Cu
1rk5 - AfDAA (mutant) + Zn + Cu
1rk6 - AfDAA + Zn + Cd
References
- ↑ Larsen NA, Turner JM, Stevens J, Rosser SJ, Basran A, Lerner RA, Bruce NC, Wilson IA. Crystal structure of a bacterial cocaine esterase. Nat Struct Biol. 2002 Jan;9(1):17-21. PMID:11742345 doi:10.1038/nsb742
