Sandbox Reserved 821

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Revision as of 16:06, 24 December 2013 by Oriane Coiscault (Talk | contribs)
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This Sandbox is Reserved from 06/12/2018, through 30/06/2019 for use in the course "Structural Biology" taught by Bruno Kieffer at the University of Strasbourg, ESBS. This reservation includes Sandbox Reserved 1480 through Sandbox Reserved 1543.
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Contents

Human C-reactive protein (CRP)

The C-reactive protein (CRP) is a plasma protein, mainly synthesized by the liver. Its concentration may increase rapidly, as much as 1000-fold or more, in response to tissue injury, infection and inflammation: It's an acute-phase protein.

CRP binds to phosphocholine which is exposed on died or dying cells and expressed on the surfaces of pathogens, and then may activate the complement system via interaction with C1q, and enhance phagocytosis by macrophages via its binding to Fcγ receptors.In addition to the fact that this protein has been highly conserved during evolution, this suggests that CRP is a very important part of the innate immune response, in the host defense.

CRp belong to the pentraxin family.


Structure of CRP

The Calcium and Phosphocholine binding sites

Interaction with C1q

Interaction with Fcγ receptors

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