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2mio
From Proteopedia
Solution NMR Structure of SH3 Domain 1 of Rho GTPase-activating Protein 10 from Homo sapiens, Northeast Structural Genomics Consortium (NESG) Target HR9129A
Function
[RHG10_HUMAN] GTPase activator for the small GTPases RhoA and Cdc42 by converting them to an inactive GDP-bound state. Essential for PTKB2 regulation of cytoskeletal organization via Rho family GTPases. Inhibits PAK2 proteolytic fragment PAK-2p34 kinase activity and changes its localization from the nucleus to the perinuclear region. Stabilizes PAK-2p34 thereby increasing stimulation of cell death (By similarity).
About this Structure
2mio is a 1 chain structure. Full experimental information is available from OCA.
Categories: Eletsky, A. | Everett, J K. | Janjua, H. | Montelione, G T. | NESG, Northeast Structural Genomics Consortium. | Pulavarti, S V.S R.K. | Sukumaran, D K. | Szyperski, T. | Wang, H. | Xiao, R. | Xu, X. | Nesg | Northeast structural genomics consortium | Protein structure initiative | Psi-biology | Structural genomic | Unknown function
