4njp

From Proteopedia

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Template:STRUCTURE 4njp

Contents 1 Proteolysis inside the membrane is a rate-governed reaction not Driven by substrate affinity 2 Function 3 About this Structure 4 Reference

Proteolysis inside the membrane is a rate-governed reaction not Driven by substrate affinity

Template:ABSTRACT PUBMED 24315097

Function

[GLPG_ECOLI] Rhomboid-type serine protease that catalyzes intramembrane proteolysis.^{[1] [2]}

About this Structure

4njp is a 1 chain structure. Full crystallographic information is available from OCA.

Reference

• Dickey SW, Baker RP, Cho S, Urban S. Proteolysis inside the Membrane Is a Rate-Governed Reaction Not Driven by Substrate Affinity. Cell. 2013 Dec 5;155(6):1270-81. doi: 10.1016/j.cell.2013.10.053. PMID:24315097 doi:http://dx.doi.org/10.1016/j.cell.2013.10.053

1. ↑ Wu Z, Yan N, Feng L, Oberstein A, Yan H, Baker RP, Gu L, Jeffrey PD, Urban S, Shi Y. Structural analysis of a rhomboid family intramembrane protease reveals a gating mechanism for substrate entry. Nat Struct Mol Biol. 2006 Dec;13(12):1084-91. Epub 2006 Nov 10. PMID:17099694 doi:10.1038/nsmb1179
2. ↑ Maegawa S, Ito K, Akiyama Y. Proteolytic action of GlpG, a rhomboid protease in the Escherichia coli cytoplasmic membrane. Biochemistry. 2005 Oct 18;44(41):13543-52. PMID:16216077 doi:10.1021/bi051363k