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4npq

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Template:STRUCTURE 4npq

Contents

The resting-state conformation of the GLIC ligand-gated ion channel

Template:ABSTRACT PUBMED 24367074

Function

[GLIC_GLOVI] Cationic channel with similar permeabilities for Na(+) and K(+), that is activated by an increase of the proton concentration on the extracellular side. Displays no permeability for chloride ions. Shows slow kinetics of activation, no desensitization and a single channel conductance of 8 pS. Might contribute to adaptation to external pH change.[1]

About this Structure

4npq is a 20 chain structure. Full crystallographic information is available from OCA.

Reference

  • Sauguet L, Shahsavar A, Poitevin F, Huon C, Menny A, Nemecz A, Haouz A, Changeux JP, Corringer PJ, Delarue M. Crystal structures of a pentameric ligand-gated ion channel provide a mechanism for activation. Proc Natl Acad Sci U S A. 2014 Jan 21;111(3):966-71. doi:, 10.1073/pnas.1314997111. Epub 2013 Dec 23. PMID:24367074 doi:http://dx.doi.org/10.1073/pnas.1314997111
  1. ↑ Bocquet N, Prado de Carvalho L, Cartaud J, Neyton J, Le Poupon C, Taly A, Grutter T, Changeux JP, Corringer PJ. A prokaryotic proton-gated ion channel from the nicotinic acetylcholine receptor family. Nature. 2007 Jan 4;445(7123):116-9. Epub 2006 Dec 10. PMID:17167423 doi:10.1038/nature05371

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