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2ynd

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Revision as of 09:02, 5 February 2014 by OCA (Talk | contribs)
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Template:STRUCTURE 2ynd

Contents

Plasmodium vivax N-myristoyltransferase in complex with a pyrazole sulphonamide inhibitor.

Template:ABSTRACT PUBMED 24451586

Function

[A5K1A2_PLAVS] Adds a myristoyl group to the N-terminal glycine residue of certain cellular proteins (By similarity).[RuleBase:RU000586]

About this Structure

2ynd is a 3 chain structure. Full crystallographic information is available from OCA.

Reference

  • Wright MH, Clough B, Rackham MD, Rangachari K, Brannigan JA, Grainger M, Moss DK, Bottrill AR, Heal WP, Broncel M, Serwa RA, Brady D, Mann DJ, Leatherbarrow RJ, Tewari R, Wilkinson AJ, Holder AA, Tate EW. Validation of N-myristoyltransferase as an antimalarial drug target using an integrated chemical biology approach. Nat Chem. 2014 Feb;6(2):112-21. doi: 10.1038/nchem.1830. Epub 2013 Dec 22. PMID:24451586 doi:http://dx.doi.org/10.1038/nchem.1830

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OCA

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