4lbl

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Template:STRUCTURE 4lbl

Contents 1 Crystal structure of Human galectin-3 CRD K176L mutant in complex with a-GM3 2 Function 3 About this Structure 4 See Also 5 Reference

Crystal structure of Human galectin-3 CRD K176L mutant in complex with a-GM3

Template:ABSTRACT PUBMED 24326249

Function

[LEG3_HUMAN] Galactose-specific lectin which binds IgE. May mediate with the alpha-3, beta-1 integrin the stimulation by CSPG4 of endothelial cells migration. Together with DMBT1, required for terminal differentiation of columnar epithelial cells during early embryogenesis (By similarity). In the nucleus: acts as a pre-mRNA splicing factor. Involved in acute inflammatory responses including neutrophil activation and adhesion, chemoattraction of monocytes macrophages, opsonization of apoptotic neutrophils, and activation of mast cells.^{[1] [2] [3]}

About this Structure

4lbl is a 1 chain structure. Full crystallographic information is available from OCA.

See Also

• Galectin

Reference

• Collins PM, Bum-Erdene K, Yu X, Blanchard H. Galectin-3 Interactions with Glycosphingolipids. J Mol Biol. 2013 Dec 8. pii: S0022-2836(13)00743-2. doi:, 10.1016/j.jmb.2013.12.004. PMID:24326249 doi:http://dx.doi.org/10.1016/j.jmb.2013.12.004

1. ↑ Fukushi J, Makagiansar IT, Stallcup WB. NG2 proteoglycan promotes endothelial cell motility and angiogenesis via engagement of galectin-3 and alpha3beta1 integrin. Mol Biol Cell. 2004 Aug;15(8):3580-90. Epub 2004 Jun 4. PMID:15181153 doi:http://dx.doi.org/10.1091/mbc.E04-03-0236
2. ↑ Henderson NC, Sethi T. The regulation of inflammation by galectin-3. Immunol Rev. 2009 Jul;230(1):160-71. doi: 10.1111/j.1600-065X.2009.00794.x. PMID:19594635 doi:10.1111/j.1600-065X.2009.00794.x
3. ↑ Haudek KC, Spronk KJ, Voss PG, Patterson RJ, Wang JL, Arnoys EJ. Dynamics of galectin-3 in the nucleus and cytoplasm. Biochim Biophys Acta. 2010 Feb;1800(2):181-189. Epub 2009 Jul 16. PMID:19616076 doi:S0304-4165(09)00194-9