2mgx

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Template:STRUCTURE 2mgx

Contents

NMR structure of SRA1p C-terminal domain

Function

[SRA1_HUMAN] Functional RNA which acts as a transcriptional coactivator that selectively enhances steroid receptor-mediated transactivation ligand-independently through a mechanism involving the modulating N-terminal domain (AF-1) of steroid receptors. Also mediates transcriptional coactivation of steroid receptors ligand-dependently through the steroid-binding domain (AF-2). Enhances cellular proliferation and differentiation and promotes apoptosis in vivo. May play a role in tumorigenesis.[1] [2] [3] [4] [5]

About this Structure

2mgx is a 1 chain structure. Full experimental information is available from OCA.

Reference

  1. ↑ Lanz RB, McKenna NJ, Onate SA, Albrecht U, Wong J, Tsai SY, Tsai MJ, O'Malley BW. A steroid receptor coactivator, SRA, functions as an RNA and is present in an SRC-1 complex. Cell. 1999 Apr 2;97(1):17-27. PMID:10199399
  2. ↑ Deblois G, Giguere V. Ligand-independent coactivation of ERalpha AF-1 by steroid receptor RNA activator (SRA) via MAPK activation. J Steroid Biochem Mol Biol. 2003 Jun;85(2-5):123-31. PMID:12943696
  3. ↑ Lanz RB, Chua SS, Barron N, Soder BM, DeMayo F, O'Malley BW. Steroid receptor RNA activator stimulates proliferation as well as apoptosis in vivo. Mol Cell Biol. 2003 Oct;23(20):7163-76. PMID:14517287
  4. ↑ Coleman KM, Lam V, Jaber BM, Lanz RB, Smith CL. SRA coactivation of estrogen receptor-alpha is phosphorylation-independent, and enhances 4-hydroxytamoxifen agonist activity. Biochem Biophys Res Commun. 2004 Oct 8;323(1):332-8. PMID:15351741 doi:http://dx.doi.org/10.1016/j.bbrc.2004.08.090
  5. ↑ Chooniedass-Kothari S, Emberley E, Hamedani MK, Troup S, Wang X, Czosnek A, Hube F, Mutawe M, Watson PH, Leygue E. The steroid receptor RNA activator is the first functional RNA encoding a protein. FEBS Lett. 2004 May 21;566(1-3):43-7. PMID:15147866 doi:http://dx.doi.org/10.1016/j.febslet.2004.03.104

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