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3wn4

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Template:STRUCTURE 3wn4

Contents

Crystal structure of human TLR8 in complex with DS-877

Template:ABSTRACT PUBMED 24474703

Function

[TLR8_HUMAN] Key component of innate and adaptive immunity. TLRs (Toll-like receptors) control host immune response against pathogens through recognition of molecular patterns specific to microorganisms. Acts via MYD88 and TRAF6, leading to NF-kappa-B activation, cytokine secretion and the inflammatory response.[1]

About this Structure

3wn4 is a 1 chain structure. Full crystallographic information is available from OCA.

Reference

  • Kokatla HP, Sil D, Tanji H, Ohto U, Malladi SS, Fox LM, Shimizu T, David SA. Structure-Based Design of Novel Human Toll-like Receptor 8 Agonists. ChemMedChem. 2014 Jan 28. doi: 10.1002/cmdc.201300573. PMID:24474703 doi:http://dx.doi.org/10.1002/cmdc.201300573
  1. ↑ Doyle SL, Jefferies CA, Feighery C, O'Neill LA. Signaling by Toll-like receptors 8 and 9 requires Bruton's tyrosine kinase. J Biol Chem. 2007 Dec 21;282(51):36953-60. Epub 2007 Oct 11. PMID:17932028 doi:10.1074/jbc.M707682200

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