4n19

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Template:STRUCTURE 4n19

Contents

Structural basis of conformational transitions in the active site and 80 s loop in the FK506 binding protein FKBP12

Template:ABSTRACT PUBMED 24405377

Function

[FKB1A_HUMAN] Keeps in an inactive conformation TGFBR1, the TGF-beta type I serine/threonine kinase receptor, preventing TGF-beta receptor activation in absence of ligand. Recruites SMAD7 to ACVR1B which prevents the association of SMAD2 and SMAD3 with the activin receptor complex, thereby blocking the activin signal. May modulate the RYR1 calcium channel activity. PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides.[1] [2]

About this Structure

4n19 is a 1 chain structure. Full crystallographic information is available from OCA.

See Also

Reference

  • Mustafi SM, Brecher M, Zhang J, Li H, Lemaster DM, Hernandez G. Structural basis of conformational transitions in the active site and 80's loop in the FK506 binding protein FKBP12. Biochem J. 2014 Jan 10. PMID:24405377 doi:http://dx.doi.org/10.1042/BJ20131429
  1. ↑ Chen YG, Liu F, Massague J. Mechanism of TGFbeta receptor inhibition by FKBP12. EMBO J. 1997 Jul 1;16(13):3866-76. PMID:9233797 doi:10.1093/emboj/16.13.3866
  2. ↑ Yamaguchi T, Kurisaki A, Yamakawa N, Minakuchi K, Sugino H. FKBP12 functions as an adaptor of the Smad7-Smurf1 complex on activin type I receptor. J Mol Endocrinol. 2006 Jun;36(3):569-79. PMID:16720724 doi:10.1677/jme.1.01966

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