4c3m
From Proteopedia
Contents |
Structure of wildtype PII from S. elongatus at medium resolution
Template:ABSTRACT PUBMED 24519945
Function
[GLNB_SYNE7] P-II indirectly controls the transcription of the GS gene (glnA). P-II prevents NR-II-catalyzed conversion of NR-I to NR-I-phosphate, the transcriptional activator of glnA. When P-II is phosphorylated, these events are reversed. In nitrogen-limiting conditions, when the ratio of Gln to 2-ketoglutarate decreases, P-II is phosphorylated which allows the deadenylation of glutamine synthetase (GS), thus activating the enzyme.
About this Structure
4c3m is a 3 chain structure with sequence from Pcc 6301. Full crystallographic information is available from OCA.
Reference
- Zeth K, Fokina O, Forchhammer K. Structural Basis and Target-Specific Modulation of ADP Sensing by the Synechococcus elongatus PII Signaling Protein. J Biol Chem. 2014 Feb 11. PMID:24519945 doi:http://dx.doi.org/10.1074/jbc.M113.536557
