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CREB-binding protein

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Revision as of 11:33, 20 November 2014 by Michal Harel (Talk | contribs)

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Image:1kbh.png

Crystal structure of CREB-binding protein (green) complex with nuclear receptor coactivator (grey) 1kbh

Template:STRUCTURE 3p1c

CREB-binding protein (CBP) is a transcription activator. CREB is cAMP response element-binding protein which is a cellular transcription factor which binds to DNA and regulates transcription. CBP acetylates histones. It binds to phosphorylated CREB and enhances its activity. CBP contains several domains. Among them the lysine recognition bromodomain; domains KIX, TAZ1 and TAZ2 which bind sequences spanning the transactivation domain of transcription factor p53; IBiD which binds the interferon response; ZZ is a zinc-binding motif; CH1 interacts with the N-terminal of p73.