Sandbox Reserved 938

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This Sandbox is Reserved from 01/04/2014, through 30/06/2014 for use in the course "510042. Protein structure, function and folding" taught by Prof Adrian Goldman, Tommi Kajander, Taru Meri, Konstantin Kogan and Juho Kellosalo at the University of Helsinki. This reservation includes Sandbox Reserved 923 through Sandbox Reserved 947.

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Contents 1 Introduction 2 The structure of MANF 2.1 N-terminal domain 2.2 C-terminal domain 3 MANF in disease

Introduction

Mesencephalic astrocyte-derived neurotrophic factor (MANF), protein family, discovery as a protein, biological function (toxin studies, stroke, etc. - Mikko, ER-stress - Apostolou, Glembotski, etc). Receptor unknown despite broad array of function. Knock-out has been recently published, giving more broader insight into the structure-function relationship of the protein.

The structure of MANF

MANF has 2 distinc and also functionally different domains, C-terminal and N-terminal, connected by a loop. SS-bridges?

N-terminal domain

Green link, removes C-terminal domain. Roles (Parkash, Hellman).

C-terminal domain

Green link, removes N-terminal domain. Roles (Parkash, Hellman).

MANF in disease