Background
Monoglyceride lipase is part of the α/β hydrolase family, having a Ser-His-Asp catalytic triad (Celemnte et al. 2012). MGL terminates the signaling of a primary endocannabinoid, 2-AG (Savinainen et al 2010). MGL is able to hydrolyze 2-arachidonoylglycerol into arachidonic acid and glycerol (Bertrand et al. 2010). One of the key features of MGL is the hydrophobic tunnel, which has been suggested to provide a model for drug research.
Metabolic Role
Component of Endocannabinoid System
Structure
Catalytic triad
Catalytic Triad of MGL structure
Binding
Ligand Binding Site
Ligand within the Overall Structure of MGL
Overall Reaction
Literature
Additional Resources
References
External links
