4pwy

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Template:STRUCTURE 4pwy

Contents 1 Crystal structure of a Calmodulin-lysine N-methyltransferase fragment 2 Disease 3 Function 4 About this Structure 5 Reference

Crystal structure of a Calmodulin-lysine N-methyltransferase fragment

Disease

[CMKMT_HUMAN] Atypical hypotonia - cystinuria syndrome;2p21 microdeletion syndrome without cystinuria;2p21 microdeletion syndrome.

Function

[CMKMT_HUMAN] Catalyzes the trimethylation of 'Lys-116' in calmodulin.^[1]

About this Structure

4pwy is a 1 chain structure. Full crystallographic information is available from OCA.

Reference

1. ↑ Magnani R, Dirk LM, Trievel RC, Houtz RL. Calmodulin methyltransferase is an evolutionarily conserved enzyme that trimethylates Lys-115 in calmodulin. Nat Commun. 2010 Jul 27;1:43. doi: 10.1038/ncomms1044. PMID:20975703 doi:http://dx.doi.org/10.1038/ncomms1044