Penicillin-binding protein
From Proteopedia
Penicillin-binding protein (PBP) is a bacterial protein which binds antibiotics. There are several PBPs in each organism. PBPs are involved in the synthesis of bacterial cell wall. Their inhibition by antibiotics leads to irregularities in the cell wall and eventual bacterial death. The PBP are classified to high-molecular weight and low-molecular weight groups. D-alanyl-D-alanine carboxypeptidase (DDP) which cross-links peptidoglycan chains is also PBP.
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3D structures of penicillin-binding protein
Updated on 19-August-2014
PBP
1qme, 1rp5, 2z2l – SpPBP 2X – Streptococcus pneumoniae
1k25, 1pyy – SpPBP 2X (mutant)
2fff - SpPBP 1B
2bg1, 2xd5 - SpPBP 1B (mutant)
2c6w, 2v2f - SpPBP 1A
2wad, 2wae, 2waf – SpPBP 2B
1hd8, 1nj4, 1sdn – EcPBP 5 (mutant) – Escherichia coli
2ex2 – EcPBP 4
1nzo, 1nzu – EcPBP 5
3it9 – EcPBP 6
3vma – EcPBP 1B
1mwr, 1vqq - SaPBP 2A (mutant) – Staphylococcus aureus
2olu, 3dwk – SaPBP 2
3vsk - SaPBP 3
1tvf – SaPBP 4
1w5d – BsPBP 4A – Bacillus subtilis
3mfd – BsPBP 5*
2oqo – AaPBP 1A – Aquifex aeolicus
3equ – NgPBP 2 – Neisseria gonorrhoeae
3eqv – NgPBP 2 (mutant)
3a3d – HiPBP 4 – Haemophilus influenza
3a3j – HiPBP 5
3lo7, 3un7 – MtPBP A – Mycobacterium tuberculosis
3oc2, 3pbn – PaPBP 3 – Pseudomonas aeruginosa
3tg9 – PBP – Bacillus halodurans
3udf – AbPBP – Acinetobacter baumannii
3zg7 – LmPBP 4 – Listeria monocytogenes
PBP complex with antibiotics
1qmf, 2z2m, 2zc3, 2zc4, 2zc5, 2zc6 – SpPBP 2X + antibiotic
1mwu, 1mwt, 1mws - SaPBP 2A (mutant) + antibiotic
2uwx - SaPBP 1B (mutant) + antibiotic
2olv - SaPBP 2 + antibiotic
3zfz, 3zg0, 4dki - SaPBP 2’ + antibiotic
3vsl - SaPBP 3 + antibiotic
3hum, 3hun - SaPBP 4 (mutant) + antibiotic
2c5w - SpPBP 1A + antibiotic
2jch, 2je5, 2xd1 - SpPBP 1B (mutant) + antibiotic
2ex6, 2ex8, 2ex9, 2exa, 2exb - EcPBP 4 + antibiotic
3beb, 3bec, 3mzd, 3mze, 3mzf - EcPBP 5 + antibiotic
3ita - EcPBP 6 + antibiotic
3fwl, 3fwm – EcPBP 1B + antibiotic
3a3e, 3a3f, 3a3i – HiPBP 4 + antibiotic
3ocl, 3ocn, 3pbo, 3pbq, 3pbr, 3pbs, 3pbt, 4kqo, 4kqq, 4kqr, 4l0l – PaPBP 3 + antibiotic
3nb6, 3nb7 - AaPBP 1A + antibiotic
3udi, 3udx, 3ue0, 3ue1 - AbPBP + antibiotic
PBP complex with boronic acid derivatives
1z6f – EcPBP 5 + boronic acid
2y2g, 2y2h, 2y2i, 2y2j, 2y2k, 2y2l, 2y2m, 2y2n, 2y2o, 2y2p, 2y2q - SpPBP 1B + boronic acid derivative
PBP complex with peptidoglycan
3itb - EcPBP 6 + peptidoglycan peptide
2j9p - BsPBP 4A + peptidoglycan peptide
3zg5 - SaPBP + peptidoglycan analog
PBP complex with other inhibitors
4fsf – PaPBP + inhibitor
D-alanyl-D-alanine carboxypeptidase
1w79, 1w8q – AcDDP – Actinomadura
3pte, 1skf – StDDP – Streptomyces
1es2, 1es3, 1es4, 1es5, 1esi, 1j9m – StDDP (mutant)
1lbu – DDP + Zn – Streptomyces albus
2wke, 1w8y, 2vgj, 2vgk, 4ben - AcDDP + antibiotic
1cef, 1ceg, 1hvb, 1pw1, 1pw8, 1pwc, 1pwd, 1pwg – StDDP + antibiotic
2xdm, 2xk1, 2xln, 2y4a, 2y55, 2y59, 3zvt, 3zvw – AcDDP + boronic acid derivative
1ikg, 1iki – StDDP + peptidoglycan fragment
1mpl - StDDP + phosphonate inhibitor
1scw, 1sde - StDDP + cyclic phosphate inhibitor
1yqs - StDDP + sultam inhibitor
3zcz – AcDDP + inhibitor
