User:Jaakko Itkonen

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• Full Real Name: Jaakko Matias Itkonen

• Position: Student

• Institution (NO ABBREVIATIONS): University of Helsinki, Faculty Of Pharmacy, Division of Pharmaceutical Biosciences

• City, State/Province, Country: Helsinki, Finland

• Field of Expertise or Study: Pharmacy

• User:Jaakko Itkonen/Sandbox CNTF

Introduction

Ciliary neutrophic factor (CNTF) is a nerve growth factor belonging to the IL-6 family of neuropoietic cytokines. Other members of this family include leukaemie inhibitory factor (LIF), IL-6, IL-11 and oncostatin M (Wang 2012). CNTF is a roughly 22.7 kDa protein consisting of a single peptide chain of 200 amino acid residues. Like many other cytokines, CNTF is folded into a bundle of four anti-parallel α-helices (A-D), where helices A-B and C-D are connected by two cross-over loops and helices B-C by one short loop.

Fig. 1 X-ray structure of a truncated form of hCNTF (2-187)

References