Structural highlights
Evolutionary Conservation
Check, as determined by ConSurfDB. You may read the explanation of the method and the full data available from ConSurf.
Publication Abstract from PubMed
CNTO4088 is a monoclonal antibody to human IL-23. The X-ray structure of the Fab fragment revealed an unusual noncanonical conformation of CDR L1. Most antibodies with the kappa light chain exhibit a canonical structure for CDR L1 in which residue 29 anchors the CDR loop to the framework. Analysis of the residues believed to define the conformation of CDR L1 did not explain why it should not adopt a canonical conformation in this antibody. This makes CNTO4088 a benchmark case for developing prediction methods and structure-modeling tools.
Noncanonical conformation of CDR L1 in the anti-IL-23 antibody CNTO4088.,Teplyakov A, Obmolova G, Rogers A, Gilliland GL Acta Crystallogr Sect F Struct Biol Cryst Commun. 2010 Mar 1;66(Pt, 3):229-32. Epub 2010 Feb 23. PMID:20208149[1]
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.
References
- ↑ Teplyakov A, Obmolova G, Rogers A, Gilliland GL. Noncanonical conformation of CDR L1 in the anti-IL-23 antibody CNTO4088. Acta Crystallogr Sect F Struct Biol Cryst Commun. 2010 Mar 1;66(Pt, 3):229-32. Epub 2010 Feb 23. PMID:20208149 doi:10.1107/S1744309109054141
