Structural highlights
3r0i is a 2 chain structure with sequence from Ecoli. Full crystallographic information is available from OCA. For a guided tour on the structure components use FirstGlance.
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| Ligands: | , |
| Related: | 1k5h, 1onp, 1q0l |
| Gene: | dxr, ispC, yaeM, b0173, JW0168 (ECOLI) |
| Activity: | 1-deoxy-D-xylulose-5-phosphate reductoisomerase, with EC number 1.1.1.267 |
| Resources: | FirstGlance, OCA, RCSB, PDBsum |
Function
[DXR_ECOLI] Catalyzes the NADP-dependent rearrangement and reduction of 1-deoxy-D-xylulose-5-phosphate (DXP) to 2-C-methyl-D-erythritol 4-phosphate (MEP).[HAMAP-Rule:MF_00183]
Publication Abstract from PubMed
Reverse hydroxamate-based inhibitors of IspC, a key enzyme of the non-mevalonate pathway of isoprenoid biosynthesis and a potential antimalarial target, were synthesized and biologically evaluated. The binding mode of one derivative in complex with EcIspC and a divalent metal ion was clarified by X-ray analysis. Pilot experiments have demonstrated in vivo potential.
Reverse Fosmidomycin Derivatives against the Antimalarial Drug Target IspC (Dxr).,Behrendt CT, Kunfermann A, Illarionova V, Matheeussen A, Pein MK, Grawert T, Kaiser J, Bacher A, Eisenreich W, Illarionov B, Fischer M, Maes L, Groll M, Kurz T J Med Chem. 2011 Aug 25. PMID:21866890[1]
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.
References
- ↑ Behrendt CT, Kunfermann A, Illarionova V, Matheeussen A, Pein MK, Grawert T, Kaiser J, Bacher A, Eisenreich W, Illarionov B, Fischer M, Maes L, Groll M, Kurz T. Reverse Fosmidomycin Derivatives against the Antimalarial Drug Target IspC (Dxr). J Med Chem. 2011 Aug 25. PMID:21866890 doi:10.1021/jm200694q
