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The X-ray crystal structure of the Lymphocytic choriomeningitis virus nucleoprotein C-terminal immunosuppressive domain (LCMV NPDelta340) was determined to 2.0 A resolution. The structure indicates that LCMV NPDelta340, like the other structurally characterized arenaviral nucleoproteins, adopts the fold of an exonuclease. This structure provides a crucial three-dimensional template for functional exploration of the replication and immunosuppression of this prototypic arenavirus.
Structure of the LCMV nucleoprotein provides a template for understanding arenavirus replication and immunosuppression.,West BR, Hastie KM, Saphire EO Acta Crystallogr D Biol Crystallogr. 2014 Jun;70(Pt 6):1764-9. doi:, 10.1107/S1399004714007883. Epub 2014 May 30. PMID:24914986[1]
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.
References
↑ West BR, Hastie KM, Saphire EO. Structure of the LCMV nucleoprotein provides a template for understanding arenavirus replication and immunosuppression. Acta Crystallogr D Biol Crystallogr. 2014 Jun;70(Pt 6):1764-9. doi:, 10.1107/S1399004714007883. Epub 2014 May 30. PMID:24914986 doi:http://dx.doi.org/10.1107/S1399004714007883
