Dual specificity phosphatase
From Proteopedia
Dual specificity phosphatase (DUSP) is a phosphatase which acts on tyrosine, serine or threonine residues. There are several DUSP enzymes in mammals sharing a common catalytic mechanism. The DUSP include:
• Slingshot phosphatase
• Phosphatase of regenerating liver
• Cdc14
• Cdc25
• PTEN
• Myotubularin
• MAPK phosphatase see MAP kinase phosphatase
3D structures of dual specificity phosphatase
Updated on 19-June-2014
slingshot phosphatase (SSH)
2nt2 – hSSH-2L catalytic domain - human
Phosphatase of regenerating liver (RPL)
1xm2 – hPRL-1 (mutant)
1zck, 1x24 – rPRL-1 - rat
1zcl – rPRL-1 (mutant)
1r6h, 1v3a, 2mbc – hPRL-3 - NMR
Cdc14
1ohc, 1ohd – hCdc14B2 core domain
1ohe – hCdc14B2 core domain + peptide
Cdc25
1qb0, 1cwr, 1cws, 1cwt, 1ym9, 1ymd, 1ymk, 1yml, 1ys0, 2uzq – hCdc25B catalytic domain
2a2k, 2ifd, 2ifv – hCdc25B catalytic domain (mutant)
Phosphoinositide phosphatase PTEN
1d5r – hPTEN (mutant)
Myotubularin-related protein (MTMR)
1zvr – hMTMR2 PH-gram and phosphatase domains (mutant)
1zsq - hMTMR2 PH-gram and phosphatase domains (mutant) + phosphatidylinositol 3-phosphate
1m7r, 1lw3 - hMTMR2 PH-gram and phosphatase domains (mutant) + phosphate
2yf0 – hMTMR6
MAPK phosphatase
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Michal Harel, Alexander Berchansky, Joel L. Sussman, Jaime Prilusky
