Function
Poly (ADP-ribose) glycohydrolase (PARG) hydrolizes the ribose-ribose bonds in poly (ADP-ribose). Poly (ADP-ribose) are synthesized after DNA damage. PARG acts as both endo- and exoglycosidase and releases poly (ADP-ribose) of different lengths including monomers.
Disease
Relevance
PARG deficiency leads to cell death.
Structural highlights
3D Structures of poly (ADP-ribose) glycohydrolase
Updated on 24-July-2014
3sih – TcPARG – Thermonospora curvata
3sij – TcPARG (mutant)
3uek – rPARG catalytic domain - rat
4fc2 – mPARG catalytic domain - mouse
4n9y, 4n9z, 4na5, 4na6 – mPARG catalytic domain (mutant)
4a0d, 4b1g – hPARG catalytic domain (mutant) - human
PARG complex with ADP-ribose
3sig – TcPARG + ADP-ribose
4epp – TtPARG + ADP-ribose - Tetrahymena thermophila
4l2h – TtPARG (mutant) + ADP-ribose
4b1h – hPARG catalytic domain (mutant) + ADP-ribose
4na0 – mPARG catalytic domain + ADP-ribose
PARG complex with inhibitor
3sii – TcPARG + inhibitor
3uel – rPARG catalytic domain + inhibitor
4epq – TtPARG + inhibitor
4b1i, 4b1j – hPARG catalytic domain (mutant) + inhibitor
4na4 – mPARG catalytic domain + inhibitor
References
