Matriptase

Function

Matriptase or suppressor of tumorigenicity 14 protein (ST14) is an epithelial-derived, membrane multi-domain serine protease. ST14 cleaves and activates hepatocyte frowth factor/scatter factor and urokinase plasminogen. Benzamidine is an inhibitor of ST14. ST14 catalytic domain contains residues 615-855.

Disease

Relevance

ST14 is a target for anti-cancer therapy.

Structural highlights

3D Structures of matriptase

Updated on 24-July-2014

4is5 – hST14 catalytic domain - human

Matriptase complex with small molecule inhibitor

1eax – hST14 catalytic domain + benzamidine
3p8g – hST14 residues 182-422 (mutant) + benzamidine
2gv6 – hST14 catalytic domain + benzamidine derivative
4o97, 4o9v – hST14 catalytic domain + benzamidine derivative + tetrapeptide
3ncl – hST14 catalytic domain (mutant) + benzamidine derivative
2gv7, 4jz1, 4jzi, 4jyt – hST14 catalytic domain + inhibitor

Matriptase complex with polypeptide inhibitor

1eaw – hST14 catalytic domain + BPTI
3bn9 – hST14 catalytic domain + antibody
3nps, 3so3 – hST14 catalytic domain (mutant) + antibody
3p8f – hST14 residues 182-422 (mutant) + trypsin inhibitor peptide
4isl, 4isn, 4iso – hST14 catalytic domain (mutant) + Kunitz-type protease inhibitor

References