Structural highlights
4ra8 is a 5 chain structure. This structure supersedes the now removed PDB entry 3tn1. Full crystallographic information is available from OCA. For a guided tour on the structure components use FirstGlance.
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| Resources: | FirstGlance, OCA, RCSB, PDBsum |
Function
[CCL3_HUMAN] Monokine with inflammatory and chemokinetic properties. Binds to CCR1, CCR4 and CCR5. One of the major HIV-suppressive factors produced by CD8+ T-cells. Recombinant MIP-1-alpha induces a dose-dependent inhibition of different strains of HIV-1, HIV-2, and simian immunodeficiency virus (SIV).[1]
References
- ↑ Cocchi F, DeVico AL, Garzino-Demo A, Arya SK, Gallo RC, Lusso P. Identification of RANTES, MIP-1 alpha, and MIP-1 beta as the major HIV-suppressive factors produced by CD8+ T cells. Science. 1995 Dec 15;270(5243):1811-5. PMID:8525373
