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Contents 1 Haptoglobin-Hemoglobin Structure 2 Function 3 Disease 4 Relevance 5 Structural highlights 6 References

Haptoglobin-Hemoglobin Structure

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Haptoglobin 1-1 (Hp), an abundant glycoprotein in blood binds free hemoglobin (Hb) dimers in one of the strongest non-covalent binding events known in biology.

Function

During intravascular hemolysis Hb which is physiological a tetramer is released from red blood cells in to the extracellular environment. Hb then dissociates into dimer exposing . Hp binds shields Hb and shields these redox active residues and exposes and epiptope recognized by the multifunctional receptor, CD163.

Disease

Intravascular hemolysis is implicated in various diseases

Relevance

Structural highlights

(http://www.umass.edu Igor)

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References

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