Death-associated protein kinase

Death-associated protein kinase (DAPK) is a multi-domain serine/threonine kinase which regulates cell death mechanisms and has tumor suppression functions. DAPK1 is a positive mediator of γ-interferon induced programmed cell death. DAPK2 is a calcium/calmodulin dependent kinase involved in multiple cell signaling pathways which trigger cell survival. DAPK3 or zipper-interacting protein kinase is involved in the regulation of apoptosis.