Glyoxalase

From Proteopedia

Revision as of 09:41, 15 March 2016 by Michal Harel (Talk | contribs)
Jump to: navigation, search

Template:STRUCTURE 1qin

Contents

Function

Glyoxalase (GLO) is part of glyoxalase system which detoxify the highly toxic methylglyoxal and other aldehydes produced by metabolism[1].

  • GLO1 catalyzes the conversion of glutathione and methylglyoxal to lactoylglutathione.
  • GLO2 is a metalloenzyme which catalyzes the hydrolysis of lactoylglutathione to glutathione and lactate. GLO2 exists as cytosolic and mitochondrial forms. For details on GLO2 see Leishmania infantum Glyoxalase II.

Relevance

GLO1 is a target for drugs against bacteria, protozoans and cancer[2].

3D structures of glyoxalase

Updated on 15-March-2016

References

  1. ↑ Dixon DP, Cummins L, Cole DJ, Edwards R. Glutathione-mediated detoxification systems in plants. Curr Opin Plant Biol. 1998 Jun;1(3):258-66. PMID:10066594
  2. ↑ Thornalley PJ. The glyoxalase system in health and disease. Mol Aspects Med. 1993;14(4):287-371. PMID:8277832

Proteopedia Page Contributors and Editors (what is this?)

Michal Harel, Alexander Berchansky, Joel L. Sussman

Retrieved from "http://52.214.119.220/wiki/index.php/Glyoxalase"
Personal tools