Isopenicillin N synthase

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Isopenicillin N synthase (IPNS) is an iron-dependent enzyme which catalyzes the formation of isopenicillin N (IPN) from the tripeptide aminoadipoyl-cysteine-valine (ACV). IPNS participates in the biosynthesis of penicillin and cephalosporin antibiotics. The active site of IPNS contains an Fe atom. The reaction involves the reduction of O2 molecule to H2O.

3D structures of isopenicillin N synthase

Updated on 30-April-2015

Proteopedia Page Contributors and Editors (what is this?)

Michal Harel, Alexander Berchansky

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