Helicobacter pylori (H.pylori) is a class I human pathogen that is involved in causing gastric ulcers and stomach cancers. Its two nickel dependent enzymes - Urease and NiFe-H2ase, provides it a unique ability to survive and colonize in acidic human stomach. Urease catalyzes the conversion of urea to ammonia and carbamate which neutralizes its local acidic environment. Several accessory proteins play a crucial role in the maturation of Urease. UreE is urease-specific Nickel metallochaperone that is involved in the delivery nickel to urease.
Function
UreE delivers Nickel to urease.
Disease
Relevance
Structural highlights
Apo-UreE from H.pylori is a dimer which becomes tetrameric (dimer of dimer) when bound to metal. HpUreE can bind one Ni(II) and one Zn (II) per dimer. The nickel binding site is six-coordinate while the Zn is bound in a tetrahedral geometry.
Headline text
This is a sample scene created with SAT to by Group, and another to make of the protein. You can make your own scenes on SAT starting from scratch or loading and editing one of these sample scenes.
References
[http://]
