Helicobacter pylori (H.pylori) is a class I human pathogen that is involved in causing gastric ulcers and stomach cancers. Its two nickel dependent enzymes - Urease and NiFe-H2ase, provides it a unique ability to survive and colonize in acidic human stomach. Urease catalyzes the conversion of urea to ammonia and carbamate which neutralizes its local acidic environment. Several accessory proteins play a crucial role in the maturation of Urease. UreE is urease-specific Nickel metallochaperone that is involved in the delivery nickel to urease.
Function
UreE delivers Nickel to urease.
Disease
Relevance
Structural highlights
Apo-UreE from H.pylori is a dimer which becomes tetrameric (dimer of dimer) when bound to metal. HpUreE can bind one Ni(II) and one Zn (II) per dimer. The nickel binding site is six-coordinate while the Zn is bound in a tetrahedral geometry.
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