4wpe

Structural highlights

Function

[CYK2_YEAST] Throughout most of the cell cycle it forms a double ring that coincides with the septins. After the onset of mitosis, forms a ring-like structure which colocalizes with the medial actin ring. Mediates cytoskeletal rearrangements required for cytokinesis. In conjunction with the medial actin ring exhibits contraction-like action.^{[1] [2]}

References

1. ↑ Sanchez-Diaz A, Marchesi V, Murray S, Jones R, Pereira G, Edmondson R, Allen T, Labib K. Inn1 couples contraction of the actomyosin ring to membrane ingression during cytokinesis in budding yeast. Nat Cell Biol. 2008 Apr;10(4):395-406. doi: 10.1038/ncb1701. Epub 2008 Mar 16. PMID:18344988 doi:http://dx.doi.org/10.1038/ncb1701
2. ↑ Nishihama R, Schreiter JH, Onishi M, Vallen EA, Hanna J, Moravcevic K, Lippincott MF, Han H, Lemmon MA, Pringle JR, Bi E. Role of Inn1 and its interactions with Hof1 and Cyk3 in promoting cleavage furrow and septum formation in S. cerevisiae. J Cell Biol. 2009 Jun 15;185(6):995-1012. PMID:19528296 doi:http://dx.doi.org/jcb.200903125