Structural highlights
Publication Abstract from PubMed
We report the development of a new heterobase that is held together through reversible bonding. The so-formed cross-link adds strong stabilization to the DNA duplex. Despite this, the cross-link opens and closes through reversible imine bonding. Moreover, even enzymatic incorporation of the cross-link is possible. The new principle can be used to stabilize DNA duplexes and nanostructures that otherwise require high salt concentrations, which may hinder biological applications.
"Post-It" Type Connected DNA Created with a Reversible Covalent Cross-Link.,Tomas-Gamasa M, Serdjukow S, Su M, Muller M, Carell T Angew Chem Int Ed Engl. 2014 Nov 28. doi: 10.1002/anie.201407854. PMID:25446281[1]
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.
References
- ↑ Tomas-Gamasa M, Serdjukow S, Su M, Muller M, Carell T. "Post-It" Type Connected DNA Created with a Reversible Covalent Cross-Link. Angew Chem Int Ed Engl. 2014 Nov 28. doi: 10.1002/anie.201407854. PMID:25446281 doi:http://dx.doi.org/10.1002/anie.201407854
