Molecular Playground/E. coli ClpP

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Here in the Chien lab, we study how proteolysis plays a large part in protein quality control. The maintenance and timely destruction of protein levels plays an important role during cell homeostasis and cell transitions/differentiation, yet much of what governs these processes has yet to be fully understood.

Caption for this structure

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References

1. ClpP: A structurally dynamic protease regulated by AAA+ proteins. Alexopoulos JA et. al (2012 J Struct Bio)

2.ClpA and ClpX ATPases bind simultaneously to opposite ends of ClpP peptidase to form active hybrid complexes. Ortega J et. al (2004 J. Struct Biol.)

Acknowledgements

Kamal Joshi, Joanne Lau, Jing Liu, Rob Vass

Proteopedia Page Contributors and Editors (what is this?)

Robert Vass, Lisa Hernandez

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