1mq0

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Image:1mq0.gif


PDB ID 1mq0

Drag the structure with the mouse to rotate
, resolution 2.40Å
Ligands: ,
Activity: Cytidine deaminase, with EC number 3.5.4.5
Related: 1JTK


Resources: FirstGlance, OCA, PDBsum, RCSB
Coordinates: save as pdb, mmCIF, xml



Crystal Structure of Human Cytidine Deaminase


Overview

Human cytidine deaminase (CDA) is an enzyme prominent for its role in catalyzing metabolic processing of nucleoside-type anticancer and antiviral agents. It is thus a promising target for the development of small molecule therapeutic adjuvants. We report the first crystal structure of human CDA as a complex with a tight-binding inhibitor, diazepinone riboside 1. The structure reveals that inhibitor 1 is able to establish a canonical pi/pi-interaction with a key active site residue, Phe 137.

About this Structure

1MQ0 is a Single protein structure of sequence from Homo sapiens. Full crystallographic information is available from OCA.

Reference

Structure of human cytidine deaminase bound to a potent inhibitor., Chung SJ, Fromme JC, Verdine GL, J Med Chem. 2005 Feb 10;48(3):658-60. PMID:15689149

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