3rbw

Structural highlights

Function

[SPIR1_HUMAN] Acts as a actin nucleation factor, remains associated with the slow-growing pointed end of the new filament. Involved in intracellular vesicle transport along actin fibers, providing a novel link between actin cytoskeleton dynamics and intracellular transport. Required for asymmetric spindle positioning and asymmetric cell division during meiosis. Required for normal formation of the cleavage furrow and for polar body extrusion during female germ cell meiosis.^{[1] [2]}

References

1. ↑ Kerkhoff E, Simpson JC, Leberfinger CB, Otto IM, Doerks T, Bork P, Rapp UR, Raabe T, Pepperkok R. The Spir actin organizers are involved in vesicle transport processes. Curr Biol. 2001 Dec 11;11(24):1963-8. PMID:11747823
2. ↑ Pfender S, Kuznetsov V, Pleiser S, Kerkhoff E, Schuh M. Spire-type actin nucleators cooperate with Formin-2 to drive asymmetric oocyte division. Curr Biol. 2011 Jun 7;21(11):955-60. doi: 10.1016/j.cub.2011.04.029. Epub 2011, May 27. PMID:21620703 doi:http://dx.doi.org/10.1016/j.cub.2011.04.029