Structural highlights
Function
[GELA_DICDI] F-actin cross-linking protein.
Evolutionary Conservation
Check, as determined by ConSurfDB. You may read the explanation of the method and the full data available from ConSurf.
Publication Abstract from PubMed
Dictyostelium discoideum filamin (ddFLN) is a two-chain F-actin crosslinking protein with an N-terminal actin-binding domain and a rod domain constructed from six tandem repeats of a 100 residue motif that has an immunoglobulin (Ig) fold. We report the 2.8 A resolution crystal structure of a homodimer of rod repeats 4, 5 and 6. The two chains are arranged in an antiparallel fashion and form an elongated element, which is shortened, however, compared to a fully extended, linear configuration because the long axis of each Ig domain is arranged at an angle to the long axis of the rod. Same arrangement of repeats should also be present in the rod domain of human FLNa, much longer than Dictyostelium FLN, which forms an extended structure able to crosslink F-actin chains over distances of more than 1000 A.
Molecular structure of the rod domain of dictyostelium filamin.,Popowicz GM, Muller R, Noegel AA, Schleicher M, Huber R, Holak TA J Mol Biol. 2004 Oct 1;342(5):1637-46. PMID:15364587[1]
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.
See Also
References
- ↑ Popowicz GM, Muller R, Noegel AA, Schleicher M, Huber R, Holak TA. Molecular structure of the rod domain of dictyostelium filamin. J Mol Biol. 2004 Oct 1;342(5):1637-46. PMID:15364587 doi:10.1016/j.jmb.2004.08.017
