1w31
From Proteopedia
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YEAST 5-AMINOLAEVULINIC ACID DEHYDRATASE 5-HYDROXYLAEVULINIC ACID COMPLEX
Overview
The X-ray structure of the enzyme 5-aminolaevulinic acid dehydratase, (ALAD) from yeast complexed with the competitive inhibitor, 5-hydroxylaevulinic acid has been determined at a resolution of 1.9 A. The, structure shows that the inhibitor is bound by a Schiff-base link to one, of the invariant active-site lysine residues (Lys263). The inhibitor, appears to bind in two well defined conformations and the interactions, made by it suggest that it is a very close analogue of the substrate, 5-aminolaevulinic acid (ALA).
About this Structure
1W31 is a Single protein structure of sequence from Saccharomyces cerevisiae with ZN and SHO as ligands. Active as Porphobilinogen synthase, with EC number 4.2.1.24 Structure known Active Site: AC1. Full crystallographic information is available from OCA.
Reference
Structure of yeast 5-aminolaevulinic acid dehydratase complexed with the inhibitor 5-hydroxylaevulinic acid., Erskine PT, Coates L, Newbold R, Brindley AA, Stauffer F, Beaven GD, Gill R, Coker A, Wood SP, Warren MJ, Shoolingin-Jordan PM, Neier R, Cooper JB, Acta Crystallogr D Biol Crystallogr. 2005 Sep;61(Pt 9):1222-6. Epub 2005, Aug 16. PMID:16131755
Page seeded by OCA on Mon Nov 5 17:23:55 2007
Categories: Porphobilinogen synthase | Saccharomyces cerevisiae | Single protein | Beaven, G.D.E. | Brindley, A.A. | Coates, L. | Cooper, J.B. | Erskine, P.T. | Gill, R. | Neier, R. | Newbold, R. | Shoolingin-Jordan, P.M. | Stauffer, F. | Warren, M.J. | Wood, S.P. | SHO | ZN | Aldolase | Dehydratase | Heme biosynthesis | Lyase | Tetrapyrrole synthesis | Tim barrel | Zinc
