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1w31

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Revision as of 15:18, 5 November 2007 by OCA (Talk | contribs)
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Image:1w31.gif

1w31, resolution 1.9Å

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YEAST 5-AMINOLAEVULINIC ACID DEHYDRATASE 5-HYDROXYLAEVULINIC ACID COMPLEX

Overview

The X-ray structure of the enzyme 5-aminolaevulinic acid dehydratase, (ALAD) from yeast complexed with the competitive inhibitor, 5-hydroxylaevulinic acid has been determined at a resolution of 1.9 A. The, structure shows that the inhibitor is bound by a Schiff-base link to one, of the invariant active-site lysine residues (Lys263). The inhibitor, appears to bind in two well defined conformations and the interactions, made by it suggest that it is a very close analogue of the substrate, 5-aminolaevulinic acid (ALA).

About this Structure

1W31 is a Single protein structure of sequence from Saccharomyces cerevisiae with ZN and SHO as ligands. Active as Porphobilinogen synthase, with EC number 4.2.1.24 Structure known Active Site: AC1. Full crystallographic information is available from OCA.

Reference

Structure of yeast 5-aminolaevulinic acid dehydratase complexed with the inhibitor 5-hydroxylaevulinic acid., Erskine PT, Coates L, Newbold R, Brindley AA, Stauffer F, Beaven GD, Gill R, Coker A, Wood SP, Warren MJ, Shoolingin-Jordan PM, Neier R, Cooper JB, Acta Crystallogr D Biol Crystallogr. 2005 Sep;61(Pt 9):1222-6. Epub 2005, Aug 16. PMID:16131755

Page seeded by OCA on Mon Nov 5 17:23:55 2007

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