2c0t
From Proteopedia
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| , resolution 2.15Å | |||||||
|---|---|---|---|---|---|---|---|
| Sites: | |||||||
| Ligands: | , , | ||||||
| Activity: | Transferase, with EC number and 2.7.10.2 2.7.10.1 and 2.7.10.2 | ||||||
| Resources: | FirstGlance, OCA, PDBsum, RCSB | ||||||
| Coordinates: | save as pdb, mmCIF, xml | ||||||
SRC FAMILY KINASE HCK WITH BOUND INHIBITOR A-641359
Overview
We describe the identification, SAR, and pharmacology of the src-family selective lck inhibitor A-770041 that prolongs the survival of major histocompatibility mismatched allografts in models of solid organ transplant rejection for greater than 65 days.
About this Structure
2C0T is a Single protein structure of sequence from Homo sapiens. Full crystallographic information is available from OCA.
Reference
Discovery of A-770041, a src-family selective orally active lck inhibitor that prevents organ allograft rejection., Burchat A, Borhani DW, Calderwood DJ, Hirst GC, Li B, Stachlewitz RF, Bioorg Med Chem Lett. 2006 Jan 1;16(1):118-22. Epub 2005 Oct 10. PMID:16216497
Page seeded by OCA on Mon Mar 31 02:14:37 2008
Categories: Homo sapiens | Single protein | Transferase | Borhani, D W. | Burchat, A. | Calderwood, D J. | Hirst, G C. | Li, B. | Loew, A. | Alternative initiation | Atp-binding | Kinase | Lipoprotein | Myristate | Nucleotide-binding | Palmitate | Phosphorylation | Sh2 domain | Sh3 domain | Tyrosine-protein kinase
