Structural highlights
4dou is a 1 chain structure with sequence from Human. Full crystallographic information is available from OCA. For a guided tour on the structure components use FirstGlance.
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| Ligands: | , , , |
| Related: | 1c28 |
| Gene: | ACDC, ACRP30, adiponectin, ADIPOQ, APM1, GBP28 (HUMAN) |
| Resources: | FirstGlance, OCA, PDBe, RCSB, PDBsum, ProSAT |
Function
[RBTN2_MOUSE] Acts with TAL1/SCL to regulate red blood cell development. Also acts with LDB1 to maintain erythroid precursors in an immature state.[1]
Publication Abstract from PubMed
Adiponectin is increasingly recognized as a potential therapeutic agent for the treatment of diabetes and other metabolic diseases. It circulates in plasma as homotrimers and higher-order oliogomers of homotrimers. To facilitate the production of active recombinant adiponectin as a therapeutic tool, we designed a single-chain globular domain adiponectin (sc-gAd) in which three monomer sequences are linked together in tandem to form one contiguous polypeptide. Here, we present the crystal structure of human sc-gAd at 2.0A resolution. The structure reveals a similar trimeric topology to that of mouse gAd protein. Trimer formation is further rigidified by three calcium ions.
Crystal structure of a single-chain trimer of human adiponectin globular domain.,Min X, Lemon B, Tang J, Liu Q, Zhang R, Walker N, Li Y, Wang Z FEBS Lett. 2012 Mar 23;586(6):912-7. Epub 2012 Feb 22. PMID:22449980[2]
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.
References
- ↑ Visvader JE, Mao X, Fujiwara Y, Hahm K, Orkin SH. The LIM-domain binding protein Ldb1 and its partner LMO2 act as negative regulators of erythroid differentiation. Proc Natl Acad Sci U S A. 1997 Dec 9;94(25):13707-12. PMID:9391090
- ↑ Min X, Lemon B, Tang J, Liu Q, Zhang R, Walker N, Li Y, Wang Z. Crystal structure of a single-chain trimer of human adiponectin globular domain. FEBS Lett. 2012 Mar 23;586(6):912-7. Epub 2012 Feb 22. PMID:22449980 doi:10.1016/j.febslet.2012.02.024
