Structural highlights
Function
[TOLIP_HUMAN] Component of the signaling pathway of IL-1 and Toll-like receptors. Inhibits cell activation by microbial products. Recruits IRAK1 to the IL-1 receptor complex. Inhibits IRAK1 phosphorylation and kinase activity.[1]
Evolutionary Conservation
Check, as determined by ConSurfDB. You may read the explanation of the method and the full data available from ConSurf.
References
- ↑ Zhang G, Ghosh S. Negative regulation of toll-like receptor-mediated signaling by Tollip. J Biol Chem. 2002 Mar 1;277(9):7059-65. Epub 2001 Dec 18. PMID:11751856 doi:http://dx.doi.org/10.1074/jbc.M109537200
